Coronary heart disease (CHD) is the most common and serious illness in the world and has been researched for many years.\nHowever, there are still no real effective ways to prevent and save patients with this disease. When patients present with\nmyocardial infarction, the most important step is to recover ischemic prefusion, which usually is accomplished by coronary artery\nbypass surgery, coronary artery intervention (PCI), or coronary artery bypass grafting (CABG). These are invasive procedures, and\npatients with extensive lesions cannot tolerate surgery. It is, therefore, extremely urgent to search for a noninvasive way to save\nischemic myocardium. After suffering from ischemia, cardiac or skeletal muscle can partly recover blood flow through angiogenesis\n(de novo capillary) induced by hypoxia, arteriogenesis, or collateral growth (opening and remodeling of arterioles)\ntriggered by dramatical increase of fluid shear stress (FSS). Evidence has shown that both of them are regulated by various crossed\npathways, such as hypoxia-related pathways, cellular metabolism remodeling, inflammatory cells invasion and infiltration, or\nhemodynamical changes within the vascular wall, but still they do not find effective target for regulating revascularization at\npresent.................
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